The role and regulation of complement activation as part of the thromboinflammation elicited in cell therapies.

摘要: Cell therapies in which the cells come into direct contact with blood and other body fluids are emerging treatment procedures for patients various diseases, such as diabetes mellitus, liver insufficiency, graft-versus-host disease. However, despite recent progress, these associated tissue loss caused by thromboinflammatory reactions. These deleterious reactions involve activation of complement coagulation cascades platelet leukocyte activation, ultimately resulting clot formation damage to implanted cells. In this concept review, we discuss basic mechanisms underlying thrombininflammatory process, special reference engagement strategies therapeutic regulation that include use selective systemic inhibitors coat surfaces The coating may also be applied modalities similar involved, including whole organ transplantation, biomaterials blood, extracorporeal procedures.