Multiple deficiencies underlie NK cell inactivity in lymphotoxin-alpha gene-targeted mice.
作者： Lynn D. Poulton , Jonathon D. Sedgwick , Heiner Korner , Ricky W. Johnstone , Alan G. Baxter
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摘要: We have evaluated the NK cell antitumor activity in lymphotoxin (LT)-deficient mice. Both cell-mediated tumor rejection and protection from experimental metastases were significantly compromised LT-α-deficient Analysis of mice revealed that absolute number αβTCR− NK1.1+ cells was reduced bone marrow thymus, but with overall proportional decreases other hemopoietic organs. In addition, potential cells, as determined by their lytic capacity perforin expression, 1.5- to 3-fold mice, compared wild-type Combined defects development effector function contribute
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