摘要: We review the evidence of pathophysiological changes in prefrontal and temporal cortices schizophrenic subjects abnormal integration physiological dynamics these two regions. The argument we develop is that some phenomena are best understood terms interactions between different areas, not only at levels physiology functional anatomy, but level cognitive sensorimotor functioning. discuss recent imaging suggesting prefronto-temporal relation to a psychological analysis experiential; symptoms schizophrenia. Cortico-cortical have been assessed connectivity eigenimages, using time series neurophysiological data obtained with positron emission tomography. results analyses suggest there profound disruption large-scale These disruptions particularly relevant if one considers many positive schizophrenia reflect failure integrate intrinsically generated behaviour concurrent perception. (C) 1995 Wiley-Liss, Inc.
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