Derived esterase activity in Drosophila sechellia contributes to evolved octanoic acid resistance.

摘要: The dietary specialist fruit fly Drosophila sechellia has evolved resistance to the secondary defence compounds produced by of its host plant, Morinda citrifolia. primary chemicals that contribute lethality M. citrifolia are medium-chain fatty acids octanoic acid (OA) and hexanoic acid. At least five genomic regions this adaptation in D. sechellia whereas fine-mapped major effect locus for OA on chromosome 3R been thoroughly analysed, remaining four toxin remain uncharacterized. To begin identify genetic basis species, we removed function well-known detoxification gene families determine whether they resistance. Previous work found evolution cytochrome P450 enzymatic activity or expression is not responsible D. sechellia. Here, tested role two other toxins - glutathione-S-transferases esterases through use pesticide synergists diethyl maleate tribufos inhibit these families. This suggests one more esterase(s)