Increased Frequency of Learning Disability in Patients With Primary Progressive Aphasia and Their First-Degree Relatives

摘要: Background Although risk factors for Alzheimer disease have been well studied, much less is known about primary progressive aphasia (PPA). Objective To demonstrate that learning disabilities (LDs) are more common in patients with PPA and their first-degree family members. Design, Setting, Patients Self-report endorsement of an individual history LD a sample 699 subjects from the Northwestern Alzheimer's Disease Center registry. We compared 3 dementia groups (PPA, typical amnestic disease, behavioral variant frontotemporal dementia) 1 elderly control group. A retrospective medical record review probands was used to obtain additional information. Main Outcome Measure Prevalence LDs among relatives. Results The members had significantly higher frequency other controls. Some families displayed unusual concentrations LD, especially dyslexia. Conclusion These results suggest may constitute factor PPA, providing clues concerning determinants selective vulnerability language network this syndrome.