Inhibitors of Mammalian Target of Rapamycin

作者: Barry D. Kahan

DOI: 10.1002/9781444355628.CH17

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参考文章(154)
U Christians, H H Radeke, M Sattler, A Linck, K F Sewing, C Kruse, H M Schiebel, Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin. Drug Metabolism and Disposition. ,vol. 20, pp. 186- 191 ,(1992)
Gabriele I. Kirchner, Michael Winkler, Lueke Mueller, Christian Vidal, Wolfgang Jacobsen, Anke Franzke, Siegfried Wagner, Stefan Blick, Michael P. Manns, Karl-Friedrich Sewing, Pharmacokinetics of SDZ RAD and cyclosporin including their metabolites in seven kidney graft patients after the first dose of SDZ RAD British Journal of Clinical Pharmacology. ,vol. 50, pp. 449- 454 ,(2000) , 10.1046/J.1365-2125.2000.00293.X
Joel D Morrisett, Ghada Abdel-Fattah, Ron Hoogeveen, Eddie Mitchell, Christie M Ballantyne, Henry J Pownall, Antone R Opekun, Jonathon S Jaffe, Suzanne Oppermann, Barry D Kahan, None, Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients. Journal of Lipid Research. ,vol. 43, pp. 1170- 1180 ,(2002) , 10.1194/JLR.M100392-JLR200
U. Christians, M. Sattler, K.-F. Sewing, Chul-Ho Yun, F. P. Guengerich, Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metabolism and Disposition. ,vol. 20, pp. 753- 761 ,(1992)
Wilfred Lieberthal, Robert Fuhro, C. Christopher Andry, Helmut Rennke, Vivian E. Abernathy, Jason S. Koh, Robert Valeri, Jerrold S. Levine, Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells. American Journal of Physiology-renal Physiology. ,vol. 281, ,(2001) , 10.1152/AJPRENAL.2001.281.4.F693
Peter J. Houghton, Hajime Hosoi, Michael B. Dilling, Glen S. Germain, Lili Shu, Robert T. Abraham, Linda N. Liu, Takuma Shikata, Richard A. Ashmun, Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells Cancer Research. ,vol. 59, pp. 886- 894 ,(1999)
F Streit, U Christians, H M Schiebel, K L Napoli, L Ernst, A Linck, B D Kahan, K F Sewing, Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry. Clinical Chemistry. ,vol. 42, pp. 1417- 1425 ,(1996) , 10.1093/CLINCHEM/42.9.1417