Surface functionalization-induced enhancement in surface properties and biocompatibility of polyaniline nanofibers

摘要: Nanofibers of polyaniline (PAni) have been synthesized by a dilute polymerization method and functionalized 1% glutaraldehyde solution in phosphate buffer (PBS) (pH = 7.4) thin films to introduce polar chemical group order develop novel bioactive platform for tissue engineering applications. TEM estimates the nanofibers an average diameter 35.66 nm. FESEM images confirm presence interconnected nanofibrous structures PAni powder highly entangled morphology films. Thermogravimetric analysis indicates enhanced thermal stability (PNFs) after functionalization. UV-visible absorption photoluminescence studies demonstrate that PNFs are emeraldine base (EB) form before FTIR NMR spectroscopic reveal successful incorporation hydroxyl (–OH) aldehyde (–CHO) groups into PNFs. Contact angle measurements increase wettability surface functionalization as contact decreases from 76.2° 52.1°. Surface energy calculations using OWRK (Owens, Wendt, Rabel Kaelble) AB (acid–base) methods show polarity surface, endowing it with biocompatibility. Membrane tests less haemolysis activity surface-functionalized (SF-PNFs). MTT assay human peripheral blood mononuclear cells (PBMC) shows significant cell viability The non-cytotoxic effects SF-PNFs make them biocompatible scaffold biomedical applications such drug delivery.