Adrenal medullary hyperplasia. A morphometric analysis in patients with familial medullary thyroid carcinoma.

摘要: The syndrome of familial medullary thyroid carcinoma (MTC), pheochromocytoma, and parathyroid hyperplasia is inherited as an autosomal dominant trait, characterized by development bilateral multicentric thyroidal adrenal tumors. One the earliest manifestations hyperfunction in patients with this increased ratio epinephrine to norepinephrine urine. In order define morphologic correlates these early catecholamine abnormalities a large kindred MTC, morphometric analysis based on point-counting system asses volume was undertaken. These studies clearly revealed reflected two- three-fold increase weight compared age- sex-matched controls. total mass resulted from diffuse multifocal modular proliferations cells primarily within head body regions glands. results support hypothesis that pheochromocytomas MTC may, fact, represent extreme degrees nodular medulla.