Multicenter radial artery patency study (RAPS). Study design.

摘要: The use of an internal thoracic artery rather than a saphenous vein graft for left anterior descending coronary bypass is associated with improved long-term outcome. Hence, expanded arterial conduits other targets has been advocated. radial possesses number anatomic features that are technically advantageous compared conduits. This study will determine the relative patency to right and circumflex bypass. Patients graftable multivessel disease estimated ventricular ejection fraction >/= 35% undergoing nonemergent primary isolated surgery eligible. vessels must have high-grade lesions (>/= 70% diameter stenosis), target segments reasonable quality 1.5 mm in diameter. serve as their own controls. randomly allocated or territory used nonradial site. An all cases. Randomization stratified by center. endpoint determined angiography, 8-12 months postoperatively. be using McNemar's test. A sample size 464 patients provide 80% power two-tailed test (alpha = 0.05) 40% reduction rate distal anastomotic occlusion from 12% 7.2% arteries assuming 20% within-patient correlation. single interim analysis performed following completion 232 angiograms. To allow lack follow-up angiography up enrolled patients, we plan randomize total 560 patients. It also our intention assess (5-10 years) grafts studies. Three hundred were recruited 12 Canadian, university-affiliated sites November 1996 until February 1999, which 128 undergone angiography. Approximately those who followed more 1 year trial month non-left novel design helps control potential bias individual patient vessel factors. Positive results would support particular, multiple general.