Intermittent haemodiafiltration in refractory congestive heart failure: BNP and balance of inflammatory cytokines.

摘要: Background. Elevated plasma levels of cytokines have been associated with an increased risk congestive heart failure (CHF) even in people without history myocardial infarction. Here we tested the hypothesis that effective removal pro-inflammatory patients advanced CHF unresponsive to diuretic treatment is diuresis restoration and a significant reduction B-type natriuretic peptide (BNP) circulating levels. Methods. We prospectively enrolled 10 decompensated (NYHA classes III–IV). Five underwent short course intermittent haemodiafiltration (iHDF), whereas five responsive diuretics were treated intravenous boluses furosemide. Renal function was similar between two groups. Results. Excess body fluids removed both groups always resulting pulmonary congestion peripheral oedema. NYHA class improved all patients, but one by Only iHDF showed interleukin-8 monocyte chemoattractant protein-1. After end treatment, consistent responsiveness significantly lower doses oral furosemide up month follow-up. Plasma BNP before higher group, lowering after treatment. Conclusions. Our results suggest HDF for when be cleared needs restored. In our experience, cost-effective option compared continuous ultrafiltration methods because it can performed routine dialysis unit adjunctive costs machinery or personnel training.