Synthesis method of alkynylsilane derivatives

摘要: The invention provides a synthesis method of alkynylsilane derivatives. In the method, used raw materials are n-chlorobutane alkyne and trialkylchlorosilane, wherein R1 is -H or C1-C2 alkyl, R2 C1-C4 alkyl. characterized by comprising following steps: (1) preparing an n-butylmagnesium Grignard reagent; (2) (3) derivatives; (4) carrying out posttreatment; (5) products. has advantages that: 1, reaction adopted, cost low, price one third market price; 2, process simple safe, volume-production can be carried based on tonnage; 3, applied to preparation multiple medical intermediates, feedback use effect good.