The definition of ABO factors in transplantation: relation to other humoral antibody states.

摘要: The first examples of hyperacute rejection renal hemografts were seen almost 25 years ago when kidneys transplanted to ABO incompatible recipients whose plasma contained antigraft isoagglutinins. Hyperacute caused in sensitized by lymphocytotoxic antibodies is similar that the immune reaction triggers an acute inflammatory leads widespread thrombotic occlusion and devascularization graft. events after xenotransplantation between certain species are essentially same. Potential strategies avoid precipitating antigen antibody or mitigate resulting effector cascade described.