Tumor protein D52 (TPD52) and cancer—oncogene understudy or understudied oncogene?

摘要: The Tumor protein D52 (TPD52) gene was identified nearly 20 years ago through its overexpression in human cancer, and a substantial body of data now strongly supports TPD52 representing amplification target at chromosome 8q21.13. This review updates progress toward understanding the significance targeting, both tumors known to be characterized by overexpression/amplification, those where overexpression/amplification has been recently or variably reported. We highlight recent findings supporting microRNA regulation expression experimental systems describe deciphering TPD52's cellular functions, particularly cancer cells. Finally, we provide an overview potential as biomarker immunotherapeutic target. These combined studies value genes such TPD52, which are overexpressed many types, but have relatively understudied.