Quinine potently blocks single K+ channels activated by dopamine D-2 receptors in rat corpus striatum neurons
作者： Jonathan E. Freedman , Forrest F. Weight
DOI: 10.1016/0014-2999(89)90475-5
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摘要: In single channel recordings from acutely dissociated neurons of the rat corpus striatum, a membrane K+ which is activated by dopamine D-2 receptors was blocked nanomolar concentrations quinine. An intermittent partial blockade observed at 4-10 nM quinine, with voltage dependence consistent quinine binding to near extracellular surface membrane. A nearly complete current 100 and above. Such are known be too low block various other ion channels, may attained in human brain antimalarial dosages Blockade this provide useful experimental probe dopaminergic function, as an alternative receptor site neuroleptics.
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