Synthesis, characterization, antimicrobial and cytotoxicity studies of some transition metal complexes with gemifloxacin
作者： Sadeek A. Sadeek , Sherif M. Abd El-Hamid , Mahmoud M. El-Aasser
DOI: 10.1007/S00706-015-1507-7
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摘要: The preparation and characterization are reported of the new solid complexes formed from reaction gemifloxacin with Y(III), Zr(IV), La(III), Ce(IV), U(VI) at room temperature. infrared spectra proof that metal–ligand coordination involves one oxygen atom carboxylic group pyridone group. kinetic parameters thermogravimetric (TGA) its differential (DTG), such as activation energy, entropy activation, enthalpy Gibbs free energy evaluated using Coats-Redfern Horowitz-Metzger equations for ligand were carried out different n values. calculated bond length force constant, F(U=O), in uranyl complex 1.751 Ǻ 642.62 N m−1, respectively. antimicrobial activity metal was tested against some gram-positive gram-negative bacteria fungi. vitro growth inhibitory synthesized compounds human breast carcinoma (MCF-7) colon (HCT-116) cell lines investigated.
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