High prevalence of screening-detected prostate cancer among Afro-Caribbeans: the Tobago Prostate Cancer Survey.

摘要: Risk for prostate cancer is high among African Americans.We hypothesized that risk isalso in other populations of descent. Our objective was to determine the screening-detected prevalence predominantly Afro-Caribbean population on island Tobago. Male residents, ages 40–79 years, were invited participate a population-based screening using serum prostate-specific antigen (PSA) and digital rectal exam (DRE). Men with elevated PSA (≥4 ng/ml) or abnormal DRE offered an ultrasound-guided sextant biopsy gland. (2484), underwent between September 1997 June 2001. Mean age 55.9, SD 10.6 median 54 years. 14.8 ng/ml, 376 [excluding 4 values ≥ 2 above mean (1,112, 1,317, 1,818, 18,330 5.5 ng/ml 29.6], 1.2 ng/ml. Elevated and/or observed 31% (759 2484) overall, groups 40–49 (87 843, 10%), 50–59 (201 729, 28%), 60–69 (262 584, 45%), 70–79 (209 328, 64%). Of 681 men biopsied, 259 (38%, 10% 2484 screened) diagnosed cancer. Age-specific rates detected were: 1%, years; 7%, 18%, 28%, These results indicate very this West data support hypothesis descent share genetic lifestyle factors contribute their