Caloric restriction in obese pre-diabetic rats prevents beta-cell depletion, loss of beta-cell GLUT 2 and glucose incompetence

作者: M. Ohneda , L. R. Inman , R. H. Unger

DOI: 10.1007/BF00400091

关键词:

摘要: … Diet restriction for 3 months prevented the loss of glucose-stimulated insulin secretion and … obese rats was reversed or prevented by caloric restriction. We conclude that in diabetic ZDF …

参考文章(27)
Gerold M. Grodsky, Rudolph E. Fanska, The in vitro perfused pancreas. Methods in Enzymology. ,vol. 39, pp. 364- 372 ,(1975) , 10.1016/S0076-6879(75)39033-2
Ewald R. Weibel, Practical methods for biological morphometry Academic Press. ,(1979)
CONTROL OF THE HYPERGLYCEMIA OF OBESE DIABETICS BY WEIGHT REDUCTION Annals of Internal Medicine. ,vol. 17, pp. 935- 942 ,(1942) , 10.7326/0003-4819-17-6-935
B. M. Wyse, W. E. Dulin, The influence of age and dietary conditions on diabetes in the Db mouse. Diabetologia. ,vol. 6, pp. 268- 273 ,(1970) , 10.1007/BF01212237
L. Orci, M. Ravazzola, D. Baetens, L. Inman, M. Amherdt, R. G. Peterson, C. B. Newgard, J. H. Johnson, R. H. Unger, Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 9953- 9957 ,(1990) , 10.1073/PNAS.87.24.9953
A Ogawa, J H Johnson, M Ohneda, C T McAllister, L Inman, T Alam, R H Unger, Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. Journal of Clinical Investigation. ,vol. 90, pp. 497- 504 ,(1992) , 10.1172/JCI115886
J. Johnson, A. Ogawa, L. Chen, L. Orci, C. Newgard, T. Alam, R. Unger, Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes Science. ,vol. 250, pp. 546- 549 ,(1990) , 10.1126/SCIENCE.2237405
HIDEKI HIDAKA, MURUGASU NAGULESPARAN, IWAR KLIMES, RANDIL CLARK, HARUKA SASAKI, STEPHEN L. ARONOFF, BARBARA VASQUEZ, ARTHUR H. RUBENSTEIN, ROGER H. UNGER, Improvement of insulin secretion but not insulin resistance after short term control of plasma glucose in obese type II diabetics. The Journal of Clinical Endocrinology and Metabolism. ,vol. 54, pp. 217- 222 ,(1982) , 10.1210/JCEM-54-2-217
K. Capito, S. E. Hansen, C. J. Hedeskov, H. Islin, P. Thams, Fat-induced changes in mouse pancreatic islet insulin secretion, insulin biosynthesis and glucose metabolism. Acta Diabetologica. ,vol. 28, pp. 193- 198 ,(1992) , 10.1007/BF00778997