rs11614913 polymorphism in miRNA-196a2 and cancer risk: an updated meta-analysis
作者： Yuhan Liu , Anbang He , Baoer Liu , Yucheng Zhong , Xinhui Liao
DOI: 10.2147/OTT.S154211
关键词:
摘要: Several epidemiological studies have reported that polymorphisms in microRNA-196a2 (miR-196a2) were associated with various cancers. However, the results remained unverified and inconsistent different Therefore, we carried out an updated meta-analysis to elaborate effects of rs11614913 polymorphism on cancer susceptibility. A total 84 articles 35,802 cases 41,541 controls included evaluate association between miR-196a2 risk by pooled odds ratios (ORs) 95% confidence intervals (CIs). The showed is susceptibility, especially lung (homozygote comparison, OR =0.840, CI =0.734-0.961; recessive model, =0.858, =0.771-0.955), hepatocellular carcinoma (allelic contrast, =0.894, =0.800-0.998; homozygote =0.900, =0.813-0.997; =0.800, =0.678-0.944), head neck =1.076, =1.006-1.152; =1.214, =1.043-1.413). In addition, significant was found among Asian populations (allele =0.847, =0.899-0.997, P=0.038; =0.878, =0.788-0.977, P=0.017; =0.895, =0.824-0.972, P=0.008) but not Caucasians. confirmed previous may serve as a factor for patients
sci-hub.se 参考文章(111)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Dominik J. Jedlinski, Plamena N. Gabrovska, Stephen R. Weinstein, Robert A. Smith, Lyn R. Griffiths, Single nucleotide polymorphism in hsa-mir-196a-2 and breast cancer risk: a case control study. Twin Research and Human Genetics. ,vol. 14, pp. 417- 421 ,(2011) , 10.1375/TWIN.14.5.417
Mei-Li Lv, Wei-Bo Liang, Lin Zhang, Jia-Yuan Pu, Wei Dong, Yan Yang, No association between single nucleotide polymorphisms in pre-mirnas and the risk of gastric cancer in Chinese population Iranian Journal of Basic Medical Sciences. ,vol. 17, pp. 128- 133 ,(2014) , 10.22038/IJBMS.2014.2246
H. Chen, L-Y. Sun, L-L. Chen, H-Q. Zheng, Q-F. Zhang, A variant in microRNA-196a2 is not associated with susceptibility to and progression of colorectal cancer in Chinese. Internal Medicine Journal. ,vol. 42, ,(2012) , 10.1111/J.1445-5994.2011.02434.X
Z. Nikolić, D. Savić Pavićević, N. Vučić, S. Cidilko, N. Filipović, S. Cerović, V. Vukotić, S. Romac, G. Brajušković, Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population. Experimental and Molecular Pathology. ,vol. 99, pp. 145- 150 ,(2015) , 10.1016/J.YEXMP.2015.06.009
Panagiotis Dikaiakos, Maria Gazouli, Spyros Rizos, George Zografos, George E. Theodoropoulos, Evaluation of genetic variants in miRNAs in patients with colorectal cancer. Cancer Biomarkers. ,vol. 15, pp. 157- 162 ,(2015) , 10.3233/CBM-140449
Aurora Esquela-Kerscher, Frank J. Slack, Oncomirs — microRNAs with a role in cancer Nature Reviews Cancer. ,vol. 6, pp. 259- 269 ,(2006) , 10.1038/NRC1840
Kushaldeep Kaur Sodhi, Charu Bahl, Navneet Singh, Digamber Behera, Siddharth Sharma, Functional genetic variants in pre-miR-146a and 196a2 genes are associated with risk of lung cancer in North Indians. Future Oncology. ,vol. 11, pp. 2159- 2173 ,(2015) , 10.2217/FON.15.143
Xiao Xu, Qi Ling, Jianguo Wang, Haiyang Xie, Xuyong Wei, Di Lu, Qichao Hu, Xuanyu Zhang, Liming Wu, Lin Zhou, Shusen Zheng, Donor miR‐196a‐2 polymorphism is associated with hepatocellular carcinoma recurrence after liver transplantation in a Han Chinese population International Journal of Cancer. ,vol. 138, pp. 620- 629 ,(2016) , 10.1002/IJC.29821
Shi Deng, Wei Wang, Xiang Li, Peng Zhang, Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer World Journal of Surgical Oncology. ,vol. 13, pp. 297- 297 ,(2015) , 10.1186/S12957-015-0683-6