New polymorphs of ethyl 3-[(2-{[4-(hexyloxycarbonylamino-imino- methyl)-phenylamino]-methyl-1-methyl-1h-benzimidazole-5-carbonyl) -pyridin-2-yl-amino]-propionate
作者： Jaroslaw Mazurek , Mihaela Pop , Mimoun Lamkadmi
DOI:
关键词:
摘要: The invention relates to new polymorphs of the active substance ethyl 3-[(2-{[4- (hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H- benzimidazole-5-carbonyl)-pyridin-2-yl-amino]-propionate, preparation thereof and use as pharmaceutical compositions.
lens.org 参考文章(12)
Norbert Hauel, Henning Priepke, Jean Marie Stassen, Uwe Ries, Klaus Binder, Rainer Zimmermann, Wolfgang Wienen, Gerhard Mihm, Disubstituted bicyclic heterocycles, the preparation thereof, and their use as pharmaceutical compositions ,(1999)
Rainer Sobotta, Peter Sieger, Rolf Schmid, 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridine-2-yl-amino]-propionic acid ethyl ester methane sulphonate and use thereof as a medicament ,(2004)
Rainer Sobotta, Peter Sieger, Rolf Schmid, Norbert Hauel, Polymorphs of ethyl 3-[(2-{[4-(hexyloxycarbonylamino-iminomethyl)phenylamino]methyl}-1-methyl-1h-benzimidazole-5-carbonyl)pyridin-2-ylamino]propionate ,(2006)
Lin Guoqiang Ma, Process for synthesizing antithrombin inhibitor of non-asymmetric non-peptide kind ,(2006)
Dennis Mungall, BIBR-1048 Boehringer Ingelheim. Current opinion in investigational drugs. ,vol. 3, pp. 905- 907 ,(2002)
Ladislav Ulický, Terence James Kemp, Comprehensive dictionary of physical chemistry E. Horwood : PTR Prentice Hall. ,(1992)
Kerstin Schlarb, Georg Zerban, Bjoern Weyell, Arndt Hausherr, Heinz-Peter Schmitt, Rainer Hamm, Gunter Koch, Method for producing 4-(benzimidazolylmethylamino)-benzamidines ,(2005)
Richard B. Silverman, The Organic Chemistry of Drug Design and Drug Action ,(1992)
Kerstin Schlarb, Georg Zerban, Bjoern Weyell, Arndt Hausherr, Heinz-Peter Schmitt, Rainer Hamm, Gunter Koch, Improved process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides ,(2006)
Kerstin Schlarb, Georg Zerban, Bjoern Weyell, Arndt Hausherr, Heinz-Peter Schmitt, Rainer Hamm, Gunter Koch, Improved process for the preparation of 4-(benzimidazolylmethylamino)-benzamides and the salts thereof ,(2006)