Angiogenesis during Implantation, and Placental and Early Embryonic Development

摘要: Angiogenesis, the development of new capillaries from pre-existing vessels, is induced by inflammation, wound healing, immune reactions and neoplasia, required for tumour growth progression. Angiogenesis participates in a wide range ovulatory-related non-ovulatory-related reproductive processes. We present review current data pertaining to angiogenesis pregnancy, with specific emphasis on implantation placental embryonic both normal physiology processes various pathological conditions. To this goal, MEDLINE, Current Contents Index Medicus were searched studies published between 1966 August 1999. Pertinent (including human animal models) reviewed. literature supports that an essential physiological component implantation, development. also actively abnormal placenta including those observed association pre-eclampsia, restriction, maternal anaemia first-trimester other hypoxia-related conditions during pregnancy. Finally, administration inhibitor (AGM-1470) mice has been shown result complete failure due interference decidualization, yolk sac formation, vascular