Isolation And Biochemical Characterization Of The D1 And D2 Dopamine Receptors
作者： Jay A. Gingrich , Susan E. Senogles , Nourdine Amilaiky , Wei K. Chang , Joel G. Berger
DOI: 10.1007/978-1-4613-0759-4_9
关键词:
摘要: The catecholamine, dopamine, exerts physiologic effects in both the central nervous system and periphery. Dopamine systems (CNS) have been implicated several neurologic psychiatric disorders such as Parkinsonism, schizophrenia, Huntington’s chorea, Tourette’s syndrome, Lesch-Nyhan syndrome. In periphery, dopamine plays a role processes controlling renal vascular tone release of hormones, prolactin from anterior pituitary gland parathyroid hormone gland. symptoms some pathological are ameliorated through use drugs targeted toward receptors for dopamine. For example, agonists successfully used to treat Parkinson’s disease, hyperprolactinemia (prolactinomas), prevent ischemia associated with cardiovascular collapse (shock), antagonists proven useful treatment
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