Short-Term Isoflavone Intervention in the Treatment of Severe Vasomotor Symptoms after Surgical Menopause: A Case Report and Literature Review

摘要: Isoflavones are soy phytoestrogens that potentially exert various favorable effects in postmenopausal women, for example, alleviating vasomotor episodes, attenuating bone loss, and stimulating vaginal epithelial maturation. There has, however, been lack of consensus regarding those therapeutic effects. Most clinical studies isoflavones have conducted with women who had undergone natural menopause, but not surgical menopause. This study reports on a 51-year-old woman presented severe episodes after undergoing hysterectomy bilateral oophorectomy due to hypermenorrhea secondary myoma uteri. She refused hormone therapy fear adverse drug reactions so was treated oral (two capsules twice daily, equivalent at least 100 mg daily dose) 8 weeks. The number severity hot flushes her menopause-specific quality life dramatically improved from baseline values. serum resorption marker (beta C-telopeptide) decreased markedly, while maturation slightly, suggesting the potential loss intervention did adversely affect hormonal profile (FSH, LH, estradiol) liver or renal functions. Thus, could be an option experiencing