Campylobacter gene polymorphism as a determinant of clinical features of Guillain-Barre syndrome

摘要: Background: Ganglioside epitopes on Campylobacter jejuni are hypothesized as the key to development and characterization of Guillain–Barre syndrome (GBS), but a comprehensive theory has yet be established. A C gene, cst-II, involved in biosynthesis ganglioside-like lipo-oligosaccharide, shows polymorphism (Asn/Thr51) that affects ganglioside epitopes. Objective: To examine hypothesis this determines autoantibody reactivity, thereby neurologic presentations GBS. Methods: isolates were collected from 105 GBS (including its variants) 65 uncomplicated enteritis patients. The authors examined frequency cst-II connection with bacterial epitopes, reactivities against GM1, GD1a, GQ1b, patients’ findings. Results: Neuropathic strains more frequently had particular (Thr51), than did enteritic ones (85% vs 52%; p Conclusions: genetic reactivity well clinical presentation possibly through modification host-mimicking molecule. paradigm is first explain detailed pathogenesis postinfectious, autoimmune-mediated, molecular mimicry-triggering disorder.