Capillary array confocal fluorescence scanner and method

作者: Richard Alfred Mathies , Mark Alejandro Quesada , Xiaohua Chen Huang

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摘要: A laser-excited capillary array scanner including a plurality of capillaries (21) having parallel, side-by-side, coplanar relationship and confocal fluorescence detector (18) for detecting from selected interior volumes each said sequentially repetitively during electrophoresis or other separation method. The invention also relates to method analyzing (21), with single (30), by scanning passages in side-by-side relationship, periodically florescence passage any procedure.

参考文章(43)
Mathies Ra, Quesada Ma, Rye Hs, Gingrich Jc, Glazer An, High-sensitivity DNA detection with a laser-excited confocal fluorescence gel scanner. BioTechniques. ,vol. 10, pp. 616- 625 ,(1991)
Harold Swerdlow, Shaole Wu, Heather Harke, Norman J. Dovichi, Capillary gel electrophoresis for DNA sequencing : Laser-induced fluorescence detection with the sheath flow cuvette Journal of Chromatography A. ,vol. 516, pp. 61- 67 ,(1990) , 10.1016/S0021-9673(01)90204-3
Thomas A. Leonard, Martin J. Murphy, Jack B. Stubbs, Automated capillary scanning system ,(1990)
William J. Mordan, John D. Lytle, Michael W. Hunkapiller, Charles R. Connell, John A. Bridgham, Real time scanning electrophoresis apparatus for DNA sequencing ,(1986)
James Merrill Prober, Rudy Johan Dam, Charles William Robertson, Scanning fluorescent detection system ,(1988)