Factors Influencing Tumor-Selective Localization of Antibody Conjugates

摘要: Almost a century ago the concept of targeting diseased cells using “magic bullets” was proposed by Paul Ehrlich. He envisioned that antibodies, newly described Emil Behring, which could “in manner magic bullets, seek out enemy,” might be used to create highly specific bullet drugs. However, it not until 1978 tumor localized with radiolabeled antibodies in patient (Goldenberg et al., 1978). The search for suitable targets those form tumor-specific antigens, started earnest late 1970s development hybridoma technology Kohler and Milstein (1975). This ability produce large quantities monoclonal (Mabs), reagents defined monospecific nature, greatly facilitated immunological mapping cell plasma membrane provided means cytotoxic drugs specifically at cancer cells.