Decreased plasma and cerebrospinal fluid levels of stem cell factor in patients with early Alzheimer's disease.
作者： Christoph Laske , Konstantinos Stellos , Elke Stransky , Peter Seizer , Özlem Akcay
关键词:
摘要: Alzheimer's disease (AD) is characterized by massive neuronal cell loss in the brain. Stem factor (SCF) a hematopoietic growth (HGF) that promotes neuroprotective effects and supports neurogenesis In present study, we found significantly lower SCF plasma levels 30 early AD patients (908.5 +/- 181.7 pg/ml) comparison with age-matched healthy controls (1058.3 221.5 pg/ml; p = 0.006). showed significant inverse correlation dementia severity as measured ADAS-Cog (r -0.289; 0.037). cerebrospinal fluid (CSF) (131.60 43.03 15 age- gender-matched other non-inflammatory neurological (NIND) (166.03 42.5 0.017). addition, positive correlations between CXCL12 (also known SDF-1) 0.341; 0.008) CSF 0.487; < 0.001). conclusion, decreased may contribute to deficient brain support putative pathogenic clinical relevance. Further studies are needed examine whether manipulation of HGFs such could be promising new therapeutic strategy for AD.
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