New growth hormone secretagogues
作者： V. Guerlavais , D. Boeglin , J. A. Fehrentz , R. Deghenghi , V. Locatelli
DOI: 10.1007/BF02446516
关键词:
摘要: Starting from EP 51389, a potent growth hormone secretagogue (GHS), new series of GHS has been designed, synthesized and tested. This was built on gem-diamino moiety structure activity relationship study performed including N-methylation the amide bonds. Some analogues exhibited more powerful than Hexarelin, they were activeper os dog have selected as candidates for further development.
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F. A. MOMANY, C. Y. BOWERS, G. A. REYNOLDS, A. HONG, K. NEWLANDER, Conformational Energy Studies and in Vitro and in Vivo Activity Data on Growth Hormone-Releasing Peptides Endocrinology. ,vol. 114, pp. 1531- 1536 ,(1984) , 10.1210/ENDO-114-5-1531
Andrew D Howard, Scott D Feighner, Doris F Cully, Joseph P Arena, Paul A Liberator, Charles I Rosenblum, Michel Hamelin, Donna L Hreniuk, Oksana C Palyha, Jennifer Anderson, Philip S Paress, Carmen Diaz, Michael Chou, Ken K Liu, Karen Kulju McKee, Sheng-Shung Pong, Lee-Yuh Chaung, Alex Elbrecht, Mike Dashkevicz, Robert Heavens, Mike Rigby, Dalip JS Sirinathsinghji, Dennis C Dean, David G Melillo, Arthur A Patchett, Ravi Nargund, Patrick R Griffin, Julie A DeMartino, Sunil K Gupta, James M Schaeffer, Roy G Smith, Lex HT Van der Ploeg, None, A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release Science. ,vol. 273, pp. 974- 977 ,(1996) , 10.1126/SCIENCE.273.5277.974
A. A. Patchett, R. P. Nargund, J. R. Tata, M. H. Chen, K. J. Barakat, D. B. Johnston, K. Cheng, W. W. Chan, B. Butler, G. Hickey, Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 7001- 7005 ,(1995) , 10.1073/PNAS.92.15.7001
C. Y. BOWERS, F. A. MOMANY, G. A. REYNOLDS, A. HONG, On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone Endocrinology. ,vol. 114, pp. 1537- 1545 ,(1984) , 10.1210/ENDO-114-5-1537
Romano Deghenghi, Marco M. Cananzi, Antonio Torsello, Claudia Battisti, Eugenio E. Muller, Vittorio Locatelli, GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats Life Sciences. ,vol. 54, pp. 1321- 1328 ,(1994) , 10.1016/0024-3205(94)00510-9
Thomas K. Hansen, Michael Ankersen, Birgit S. Hansen, Kirsten Raun, Karin K. Nielsen, Jesper Lau, Bernd Peschke, Behrend F. Lundt, Henning Thøgersen, Nils L. Johansen, Kjeld Madsen, Peter H. Andersen, Novel orally active growth hormone secretagogues Journal of Medicinal Chemistry. ,vol. 41, pp. 3705- 3714 ,(1998) , 10.1021/JM980197U
Peter Pallai, Murray Goodman, Preparation of optically pure monoacyl 2-alkyl gem-diamines from peptide amides Journal of The Chemical Society, Chemical Communications. pp. 280- 281 ,(1982) , 10.1039/C39820000280
Masayasu Kojima, Hiroshi Hosoda, Yukari Date, Masamitsu Nakazato, Hisayuki Matsuo, Kenji Kangawa, Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. ,vol. 402, pp. 656- 660 ,(1999) , 10.1038/45230
Tohru Fukuyama, Chung-Kuang Jow, Mui Cheung, 2- and 4-Nitrobenzenesulfonamides: Exceptionally versatile means for preparation of secondary amines and protection of amines Tetrahedron Letters. ,vol. 36, pp. 6373- 6374 ,(1995) , 10.1016/0040-4039(95)01316-A
Gilles Guichard, Vincent Semetey, Claude Didierjean, André Aubry, Jean-Paul Briand, Marc Rodriguez, Effective Preparation of O-Succinimidyl-2- (tert-butoxycarbonylamino)ethylcarbamate Derivatives from β-Amino Acids. Application to the Synthesis of Urea-Containing Pseudopeptides and Oligoureas† Journal of Organic Chemistry. ,vol. 64, pp. 8702- 8705 ,(1999) , 10.1021/JO990092E