Synthesis of low molecular weight compounds with complement inhibition activity.
作者： Hoshang E Master , Shabana I Khan , Krishna A Poojari
DOI: 10.1016/S0960-894X(03)00112-4
关键词:
摘要: An attempt was made to synthesize a series of non-cytotoxic low molecular weight meta-substituted aromatic ethers (2-4, 5-7) and some their bioisosteres (14-16) evaluate activity on the activation human complement (classical pathway) intrinsic hemolytic activity. The in vitro assay results inhibition complement-mediated hemolysis by these analogues indicate that aldehydic meta substituted show inhibitory potency, while carboxylic acid Some exhibit both as well property.
elsevier.com
sci-hub.se 参考文章(12)
Michael M Frank, Louis F Fries, The role of complement in inflammation and phagocytosis Immunology Today. ,vol. 12, pp. 322- 326 ,(1991) , 10.1016/0167-5699(91)90009-I
Ying Huang, Tess De Bruyne, Sandra Apers, Yuliang Ma, Magda Claeys, Dirk Vanden Berghe, Luc Pieters, Arnold Vlietinck, Complement-inhibiting cucurbitacin glycosides from Picria fel-terrae. Journal of Natural Products. ,vol. 61, pp. 757- 761 ,(1998) , 10.1021/NP9705773
Ranjan P. Srivastava, Xiaoyan Zhu, Larry A. Walker, Robert D. Sindelar, FURTHER STRUCTURE-ACTIVITY-RELATIONSHIP STUDIES ON A/C/D-RING ANALOGS OF COMPLEMENT INHIBITOR K-76 Bioorganic & Medicinal Chemistry Letters. ,vol. 5, pp. 2429- 2434 ,(1995) , 10.1016/0960-894X(95)00423-Q
Ellen Borenfreund, Harvey Babich, Nieves Martin-Alguacil, Rapid chemosensitivity assay with human normal and tumor cells in vitro In Vitro Cellular & Developmental Biology – Plant. ,vol. 26, pp. 1030- 1034 ,(1990) , 10.1007/BF02624436
P. Gasque, Y.D. Dean, E.P. McGreal, J. VanBeek, B.P. Morgan, Complement components of the innate immune system in health and disease in the CNS. Immunopharmacology. ,vol. 49, pp. 171- 186 ,(2000) , 10.1016/S0162-3109(00)80302-1
Haregewein Assefa, Alison Nimrod, Larry Walker, Robert Sindelar, Synthesis and evaluation of potential complement inhibitory semisynthetic analogs of oleanolic acid Bioorganic & Medicinal Chemistry Letters. ,vol. 9, pp. 1889- 1894 ,(1999) , 10.1016/S0960-894X(99)00314-5
Aruna Kapil, Shalini Sharma, Effect of oleanolic acid on complement in adjuvant- and carrageenan-induced inflammation in rats. Journal of Pharmacy and Pharmacology. ,vol. 47, pp. 585- 587 ,(2011) , 10.1111/J.2042-7158.1995.TB06719.X
Anja Roos, Alma J. Nauta, Daniël Broers, Maria C. Faber-Krol, Leendert A. Trouw, Jan Wouter Drijfhout, Mohamed R. Daha, Specific inhibition of the classical complement pathway by C1q-binding peptides Journal of Immunology. ,vol. 167, pp. 7052- 7059 ,(2001) , 10.4049/JIMMUNOL.167.12.7052
S S Asghar, Pharmacological manipulation of complement system. Pharmacological Reviews. ,vol. 36, pp. 223- 244 ,(1984)
Alison Nimrod, Larry Walker, Robert Sindelar, Enantioselective synthesis and complement inhibitory assay of A/B-ring partial analogues of oleanolic acid. Bioorganic & Medicinal Chemistry Letters. ,vol. 11, pp. 1619- 1623 ,(2001) , 10.1016/S0960-894X(01)00210-4