The Role of microRNAs in the Control and Mechanism of Action of IL-10
作者： Susan R. Quinn , Luke A. O’Neill
DOI: 10.1007/978-3-662-43492-5_7
关键词:
摘要: Recent studies have shown an important interplay between Interleukin 10 (IL-10) and microRNAs. IL-10 can be directly post-transcriptionally regulated by several microRNA, including miR-106a, miR-4661, miR-98, miR-27, let7 miR-1423p/5p. miRNA targeting of has been suggested to play a role in autoimmune inflammatory diseases such as SLE, reperfusion injury asthma. Another miRNA, miR-21, indirectly regulate via downregulation the inhibitor PDCD4. The this way linked host defence modulation Mycobacterium leprae. Viral miRNAs, miR-K12-3 from Kaposi’s sarcoma-associated herpesvirus (KSHV), also decrease promote tumour development. Finally operate feedback loop, with capable regulating microRNAs, upregulating those that contribute exerting anti-inflammatory response, miR-187, downregulating are highly pro-inflammatory, miR-155. Understanding two-way regulation is giving rise new insights into cytokine.
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