Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation
作者： Jae Ho Choi , Sun Woo Jin , Chul Yung Choi , Hyung Gyun Kim , Gi Ho Lee
关键词:
摘要: Capsaicin (CPS) exerts many pharmacological effects, but any possible influence on liver fibrosis remains unclear. Therefore, we evaluated the inhibitory effects of CPS dimethylnitrosamine (DMN) and TGF-β1-induced in rats hepatic stellate cells (HSCs). inhibited DMN-induced hepatotoxicity, NF-κB activation, collagen accumulation. also suppressed increases α-SMA, type I, MMP-2, TNF-α. In addition, TGF-β1 expression (from 2.3 ± 0.1 to 1.0 0.1) Smad2/3 phosphorylation 1.5 1.1 from 1.6 0.1, respectively) by activating Smad7 0.0 0.9 via PPAR-γ induction 0.2 0.8 0.0) (p < 0.05). Furthermore, HSCs, α-SMA I expression, activation. These results indicate that can ameliorate inhibiting TGF-β1/Smad pathway
acs.org
sci-hub.se 参考文章(41)
Youngmin Lee, Scott L. Friedman, Fibrosis in the liver: acute protection and chronic disease. Progress in Molecular Biology and Translational Science. ,vol. 97, pp. 151- 200 ,(2010) , 10.1016/B978-0-12-385233-5.00006-4
Jing Tang, Kang Luo, Yan Li, Quan Chen, Dan Tang, Deming Wang, Ji Xiao, Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXRα. International Immunopharmacology. ,vol. 28, pp. 264- 269 ,(2015) , 10.1016/J.INTIMP.2015.06.007
Xing Lin, Yongxin Chen, Shujuan Lv, Shimei Tan, Shijun Zhang, Renbin Huang, Lang Zhuo, Shuang Liang, Zhongpeng Lu, Quanfang Huang, Gypsophila elegans isoorientin attenuates CCl₄-induced hepatic fibrosis in rats via modulation of NF-κB and TGF-β1/Smad signaling pathways. International Immunopharmacology. ,vol. 28, pp. 305- 312 ,(2015) , 10.1016/J.INTIMP.2015.06.021
Massimo Pinzani, Pathophysiology of Liver Fibrosis. Digestive Diseases. ,vol. 33, pp. 492- 497 ,(2015) , 10.1159/000374096
Ming-Fen Lee, Min-Lung Liu, An-Chin Cheng, Mei-Ling Tsai, Chi-Tang Ho, Wen-Shiung Liou, Min-Hsiung Pan, Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats Food Chemistry. ,vol. 138, pp. 802- 807 ,(2013) , 10.1016/J.FOODCHEM.2012.11.094
Eva Morán-Salvador, Esther Titos, Bibiana Rius, Ana González-Périz, Verónica García-Alonso, Cristina López-Vicario, Rosa Miquel, Yaacov Barak, Vicente Arroyo, Joan Clària, Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells Journal of Hepatology. ,vol. 59, pp. 1045- 1053 ,(2013) , 10.1016/J.JHEP.2013.06.023
Juan A. Suárez-Cuenca, Victoria Chagoya de Sánchez, Alberto Aranda-Fraustro, Lourdes Sánchez-Sevilla, Lidia Martínez-Pérez, Rolando Hernández-Muñoz, Partial Hepatectomy–Induced Regeneration Accelerates Reversion of Liver Fibrosis Involving Participation of Hepatic Stellate Cells Experimental Biology and Medicine. ,vol. 233, pp. 827- 839 ,(2008) , 10.3181/0709-RM-247
F. Peter Guengerich, Dong Hyun Kim, Masahiko Iwasaki, Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects Chemical Research in Toxicology. ,vol. 4, pp. 168- 179 ,(1991) , 10.1021/TX00020A008
Seong-Su Han, Young-Sam Keum, Kyung-Soo Chun, Young-Joon Surh, Suppression of phorbol ester-induced nf-κB activation by capsaicin in cultured human promyelocytic leukemia cells Archives of Pharmacal Research. ,vol. 25, pp. 475- 479 ,(2002) , 10.1007/BF02976605
Morten A Karsdal, Tina Manon-Jensen, Federica Genovese, Jacob H Kristensen, Mette J Nielsen, Jannie Marie B Sand, Niels-Ulrik B Hansen, Anne-Christine Bay-Jensen, Cecilie L Bager, Aleksander Krag, Andy Blanchard, Henrik Krarup, Diana J Leeming, Detlef Schuppan, None, Novel insights into the function and dynamics of extracellular matrix in liver fibrosis American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 308, ,(2015) , 10.1152/AJPGI.00447.2014