Effects of “in vivo” administration of baclofen on rat renal tubular function

摘要: The effects of the in vivo administration baclofen on renal tubular transport and aquaporin-2 (AQP2) expression were evaluated. In conscious animals kept metabolic cages, (0.01-1mg/kg, s.c.) induced a dose-dependent increment urine flow rate (UFR) sodium potassium excretion, associated with an increased osmolal clearance (Closm), diminished to plasma osmolality ratio (Uosm/Posm) decrease AQP2 expression. above mentioned functional parameters corroborated by using conventional techniques. Additionally, this model allowed detection diminution glucose reabsorption. Some experiments performed water-deprived or desmopressin-treated rats cages. Either water deprivation desmopressin treatment decreased UFR Uosm/Posm. Baclofen did not change Uosm/Posm rats; but it animals. These results indicate that promotes alterations proximal transport, since reabsorption was decreased. distal function also affected. Closm indicates alteration solute at ascending limb Henle's loop. controls water-deprived, rats, lead us speculate some effect endogenous vasopressin availability could be responsible for impaired concentrating ability, more than any disturbance responsiveness cells hormone.