Urinary protein and albumin excretion corrected by creatinine and specific gravity

摘要: Timed urine collections are difficult to use in clinical practice owing inaccurate making calculations of the 24-h albumin or protein excretion questionable. One our goals was assess ‘correction’ urinary and (or) by dividing these either creatinine concentration term, (specific gravity−1)×1001. The can be estimated based on patients’ gender, age weight. We studied influence physiological extremes hydration exercise, patients with suspected kidney disorders. Specimens were collected from healthy volunteers every 4 h during one period. assayed individually give us an assessment variability analytes time, then reassayed them after combining a urine. For all volunteers, mean intra-individual CVs 4-h expressed mg/24 80.0% for 96.5% total (P>0.2). reduced (SG-1)×100. This gave CV mg albumin/g 52% (P<0.1 vs. mg/g creatinine); protein/g 39% (P<0.05 albumin/[(SG-1)×100] 49% albumin)/[(SG-1)×100]; protein/[(SG-1)×100] 37% protein)/[(SG-1)×100]. 68 subjects study, strongest correlation between concentrations volume: r=0.786, P<0.001. (SG-1)×100 volume was: r=0.606, P<0.001; concentration, r=0.666, Compared more variable patients. same true if divided Protein lower dilute urines. Dividing number false negative results. values eliminated fewer negatives. Albumin increased significantly vigorous exercise. increase almost when result suggesting that decreased flow not glomerular permeability causes post-exercise albuminuria. proteinuria. A dipstick test plus optical strip reader measure protein, albumin, calculate appropriate ratios provides better screening albuminuria proteinuria than measuring only protein.