Low serum testosterone and estradiol predict mortality in elderly men.

摘要: Context: Age-related reduction of serum testosterone may contribute to the signs and symptoms aging, but previous studies report conflicting evidence about levels male mortality. No large prospective cohort study has determined a possible association between estradiol mortality in men. Objective: The main objective was examine all-cause elderly Design, Setting, Participants: We used specific gas chromatography-mass spectrometry analyze sex steroids at baseline older men who participated population-based MrOS Sweden (n = 3014; mean age, 75 yr; range, 69–80 yr). Main Outcome Measure: All-cause by levels. Results: During follow-up period 4.5 yr, 383 deaths occurred. In multivariate hazards regression models, low (within quartile 1 vs. quartiles 2–4) both [hazard ratio (HR), 1.65; 95...