Perifosine downregulates MDR1 gene expression and reverses multidrug-resistant phenotype by inhibiting PI3K/Akt/NF-κB signaling pathway in a human breast cancer cell line.

摘要: P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) is the major clinical impediment to chemotherapy of breast cancers. Down-regulation PI3K/Akt pathway has been described as related reversal MDR in cancer cells. Here, we investigated effect on phenotype perifosine, a new Akt inhibitor, cell lines. In this study, MCF-7/ADM cells and MCF-7 were treated with different concentrations perifosine. Our results suggested that perifosine reversed partially by downregulation P-gp expression inhibition PI3K/Akt/NF-κB line. The novel inhibitor may be a promising new drug due its ability reverse human