At Clinical High Risk for Psychosis: Outcome for Nonconverters

作者: Jean Addington , Barbara A. Cornblatt , Kristin S. Cadenhead , Tyrone D. Cannon , Thomas H. McGlashan

DOI: 10.1176/APPI.AJP.2011.10081191

关键词:

摘要: Objective:A major focus of early intervention research is determining the risk conversion to psychosis and developing optimal algorithms prediction. Although reported rates nonconversion vary in literature, rate always encompasses a majority (50%–85%) sample participants. Less known about outcome among this group, referred as false positive individuals. Method:A longitudinal study was conducted more than 300 prospectively identified treatment-seeking individuals meeting criteria for psychosis-risk syndrome. Participants were recruited evaluated across eight clinical centers part North American Prodrome Longitudinal Study. Over 2.5-year follow-up assessment period, 214 (71%) participants had not made transition psychosis. Results:The examined included 111 who at least 1 year data available did within duration. In 1, there significant imp...

参考文章(17)
Stephan Ruhrmann, Frauke Schultze-Lutter, Raimo K. R. Salokangas, Markus Heinimaa, Don Linszen, Peter Dingemans, Max Birchwood, Paul Patterson, Georg Juckel, Andreas Heinz, Anthony Morrison, Shôn Lewis, Heinrich Graf von Reventlow, Joachim Klosterkötter, Prediction of Psychosis in Adolescents and Young Adults at High Risk Results From the Prospective European Prediction of Psychosis Study Archives of General Psychiatry. ,vol. 67, pp. 241- 251 ,(2010) , 10.1001/ARCHGENPSYCHIATRY.2009.206
T. J. Miller, T. H. McGlashan, J. L. Rosen, K. Cadenhead, J. Ventura, W. McFarlane, D. O. Perkins, G. D. Pearlson, S. W. Woods, Prodromal Assessment With the Structured Interview for Prodromal Syndromes and the Scale of Prodromal Symptoms: Predictive Validity, Interrater Reliability, and Training to Reliability Schizophrenia Bulletin. ,vol. 29, pp. 703- 715 ,(2003) , 10.1093/OXFORDJOURNALS.SCHBUL.A007040
Elaine F. Walker, Barbara A. Cornblatt, Jean Addington, Kristin S. Cadenhead, Tyrone D. Cannon, Thomas H. McGlashan, Diana O. Perkins, Larry J. Seidman, Ming T. Tsuang, Scott W. Woods, Robert Heinssen, The relation of antipsychotic and antidepressant medication with baseline symptoms and symptom progression: A naturalistic study of the North American Prodrome Longitudinal Sample Schizophrenia Research. ,vol. 115, pp. 50- 57 ,(2009) , 10.1016/J.SCHRES.2009.07.023
Alison R Yung, Lisa J Phillips, Hok Pan Yuen, Shona M Francey, Colleen A McFarlane, Mats Hallgren, Patrick D McGorry, Psychosis prediction: 12-month follow up of a high-risk ("prodromal") group. Schizophrenia Research. ,vol. 60, pp. 21- 32 ,(2003) , 10.1016/S0920-9964(02)00167-6
Andor E. Simon, Daniel Umbricht, High remission rates from an initial ultra-high risk state for psychosis Schizophrenia Research. ,vol. 116, pp. 168- 172 ,(2010) , 10.1016/J.SCHRES.2009.10.001
Tandy J. Miller, Thomas H. McGlashan, Joanna Lifshey Rosen, Lubna Somjee, Philip J. Markovich, Kelly Stein, Scott W. Woods, Prospective Diagnosis of the Initial Prodrome for Schizophrenia Based on the Structured Interview for Prodromal Syndromes: Preliminary Evidence of Interrater Reliability and Predictive Validity American Journal of Psychiatry. ,vol. 159, pp. 863- 865 ,(2002) , 10.1176/APPI.AJP.159.5.863
Alison R. Yung, Barnaby Nelson, Carrie Stanford, Magenta B. Simmons, Elizabeth M. Cosgrave, Eoin Killackey, Lisa J. Phillips, Andreas Bechdolf, Joe Buckby, Patrick D. McGorry, Validation of "prodromal" criteria to detect individuals at ultra high risk of psychosis: 2 year follow-up. Schizophrenia Research. ,vol. 105, pp. 10- 17 ,(2008) , 10.1016/J.SCHRES.2008.07.012
A. R. Yung, P. D. McGorry, C. A. McFarlane, H. J. Jackson, G. C. Patton, A. Rakkar, Monitoring and Care of Young People at Incipient Risk of Psychosis Schizophrenia Bulletin. ,vol. 22, pp. 283- 303 ,(1996) , 10.1093/SCHBUL/22.2.283
J. Addington, K. S. Cadenhead, T. D. Cannon, B. Cornblatt, T. H. McGlashan, D. O. Perkins, L. J. Seidman, M. Tsuang, E. F. Walker, S. W. Woods, R. Heinssen, , North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research Schizophrenia Bulletin. ,vol. 33, pp. 665- 672 ,(2007) , 10.1093/SCHBUL/SBL075
J. ADDINGTON, S. VAN MASTRIGT, D. ADDINGTON, Duration of untreated psychosis: impact on 2-year outcome. Psychological Medicine. ,vol. 34, pp. 277- 284 ,(2004) , 10.1017/S0033291703001156