Natural Seven-Membered Terpene Lactones: Synthesis and Biological Activity

摘要: Until now, about 400 different natural seven-membered terpenoid lactones have been isolated from a broad spectrum of organisms. The majority (245) the reported compounds occurred in plants. A significant number (101) sevenmembered were marine fewest (22) secondary metabolites microorganisms. Thus, oxepanones are confirmed to be widely distributed that play various biological roles diverse living Research on activities principal 2-oxepanones showed most them exhibit antimicrobial, antifeedant, insecticidal, antioxidant, anti-inflammatory, and anticancer properties. Several used agriculture as plant growth inhibitors. For example, limonoids Harrisonia abyssinica suppressed sprouting seeds pathogenic Striga, which parasitizes root system crops reduces yields grains beans [1]. Derivatives also pharmacology. limonoid prieurianin, was Entandrophragma candolei (Meliaceae), could prevent obesity even diabetes patients [2]. Chiisanogenin obtained alcohol extract Acanthopanax (Eleutherococcus) senticosus is biologically active constituent treats diseases associated with glycation [3]. Despite definite success, information properties terpene still limited. Further research embellish understanding their mechanisms biogenesis nature medicine. goal present review organize respect structures, occurrence nature, synthetic accessibility, pharmacological activity. 1. Natural lactones: activity