Screening of Nanoemulsion Formulations and Identification of NB-201 as an Effective Topical Antimicrobial for Staphylococcus aureus in a Mouse Model of Infected Wounds.
作者： Yongyi Fan , Susan Ciotti , Zhengyi Cao , Rone Eisma , James Baker
DOI: 10.7205/MILMED-D-15-00186
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摘要: ABSTRACT Despite advances in antimicrobial therapies, wound infection remains a global public health concern. We aimed to formulate and assess various nanoemulsions (NEs) for potential effectiveness as stable agents suitable topic application. A total of 106 NEs were developed that varied with respect nonionic cationic surfactants. Stability testing demonstrated the tested are broadly stable, 97/106 formulations passing 2-week stability tests. Two NEs, NB-201 NB-402, selected test activity model mice. Skin abrasion wounds infected Staphylococcus aureus followed by NE treatment. Infected skin was then evaluated measuring colony forming units. reduced median bacterial counts 4 5 log compared animals treated saline, whereas NB-402 2 3 log. Additional tests on is presence human serum, at leas...
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