Substance P immunoreactivity released from rat spinal cord after kainic acid excitation of the ventral medulla oblongata: a correlation with increases in blood pressure.
作者： Yukio Takano , Jeanne E. Martin , Susan E. Leeman , Arthur D. Loewy
DOI: 10.1016/0006-8993(84)90666-8
关键词:
摘要: Abstract Kainic acid injections into the ventral medulla oblongata of sodium pentobarbital-anesthetized rats caused an almost immediate increase in mean arterial pressure which reached hypertensive levels (200mm Hg). Correlated with this rise blood was a two-fold amount SP-like immunoreactivity (SPLI) spinal cord superfusion samples. Baseline values obtained from pool two went from∼ 10pg/10min to∼ 20pg/10min. Rats pretreated intracerebroventricular serotonin neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT), were also given kainic medulla. 5,7-DHT did not block response to nor elevation SPLI superfusates. However, baseline decreased by ∼ 50% 5,7-DHT-treated rats. These findings show that activation causes superfusates conmitant pressure. responses appear be independent serotonergic systems.
elsevier.com
sci-hub.se 参考文章(14)
O. Johansson, T. Hökfelt, B. Pernow, S.L. Jeffcoate, N. White, H.W.M. Steinbusch, A.A.J. Verhofstad, P.C. Emson, E. Spindel, Immunohistochemical support for three putative transmitters in one neuron: Coexistence of 5-hydroxytryptamine, substance p- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord Neuroscience. ,vol. 6, pp. 1857- 1881 ,(1981) , 10.1016/0306-4522(81)90028-2
Å. Ljungdahl, T. Hökfelt, G. Nilsson, Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals Neuroscience. ,vol. 3, pp. 861- 943 ,(1978) , 10.1016/0306-4522(78)90116-1
V. Chan-Palay, G. Jonsson, S. L. Palay, Serotonin and substance P coexist in neurons of the rat's central nervous system Proceedings of the National Academy of Sciences of the United States of America. ,vol. 75, pp. 1582- 1586 ,(1978) , 10.1073/PNAS.75.3.1582
E. Singer, G. Sperk, P. Placheta, S.E. Leeman, Reduction of substance P levels in the ventral cervical spinal cord of the rat after intracisternal 5,7-dihydroxytryptamine injection. Brain Research. ,vol. 174, pp. 362- 365 ,(1979) , 10.1016/0006-8993(79)90863-1
A.D. Loewy, W.B. Sawyer, Substance P antagonist inhibits vasomotor responses elicited from ventral medulla in rat. Brain Research. ,vol. 245, pp. 379- 383 ,(1982) , 10.1016/0006-8993(82)90822-8
A.D. Loewy, S. McKellar, Serotonergic projections from the ventral medulla to the intermediolateral cell column in the rat. Brain Research. ,vol. 211, pp. 146- 152 ,(1981) , 10.1016/0006-8993(81)90074-3
H.W.M. Steinbusch, Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience. ,vol. 6, pp. 557- 618 ,(1981) , 10.1016/0306-4522(81)90146-9
T. L. Yaksh, T. M. Jessell, R. Gamse, A. W. Mudge, S. E. Leeman, Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo Nature. ,vol. 286, pp. 155- 157 ,(1980) , 10.1038/286155A0
P. G. Guertzenstein, Ann Silver, Fall in blood pressure produced from discrete regions of the ventral surface of the medulla by glycine and lesions The Journal of Physiology. ,vol. 242, pp. 489- 503 ,(1974) , 10.1113/JPHYSIOL.1974.SP010719
Tony L. Yaksh, Thomas A. Rudy, Chronic catheterization of the spinal subarachnoid space. Physiology & Behavior. ,vol. 17, pp. 1031- 1036 ,(1976) , 10.1016/0031-9384(76)90029-9