WebProAnalyst: an interactive tool for analysis of quantitative structure–activity relationships in protein families
作者： V. A. Ivanisenko , A. M. Eroshkin , N. A. Kolchanov
DOI: 10.1093/NAR/GKI421
关键词:
摘要: WebProAnalyst is a web-accessible analysis tool (http://wwwmgs.bionet.nsc.ru/mgs/programs/panalyst/) designed for scanning quantitative structure-activity relationships in protein families. The allows users to searchcorrelations between activity and physicochemical characteristics (i.e. hydrophobicity or alpha-helical amphipathicity) queried sequences. uses aligned amino acid sequences data on (pK, K m , ED 5 0 among others). implements methods of the known ProAnalyst package, including multiple linear regression sequence-activity correlation coefficient. In addition, incorporates method based neural networks. reports list sites family, parameters (including values) site values. useful search residues that are important function/activity. Furthermore, may be helpful designing protein-engineering experiments.
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oxfordjournals.org参考文章(18)
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