Epigenetics in the pathogenesis and pathophysiology of psoriasis vulgaris.

摘要: Epigenetic phenomena, including DNA methylation, histone modification, and genetic regulation by miRNAs, are potentially heritable regulatory changes that not attributed to direct alterations in the sequence of base pairs. They may explain link between psoriasis risk alleles disease development, as possess various potentials undergo epigenetic modification. Multiple genes involved pathogenesis demonstrate abnormal methylation patterns those epidermal differentiation proliferation, immunity, cell cycle, apoptosis, inflammation, IFN-γ TNF-α signaling. Hypoacetylation H4 is observed peripheral blood mononuclear cells psoriatic patients, degree hypoacetylation inversely correlated PASI score. Investigators have reported both increased decreased expression miRNAs patients with psoriasis, described speculated a number possible mechanisms for their roles pathogenesis. Interestingly, altered appear be normalized treatment biologics directed at inhibition. However, attempts directly correlate been limited thus far, correlating miRNA levels phenotypes can challenging inconsistent. Hopefully, goal drawing clinically relevant conclusions about role epigenetics will aided recent methods enable fast sensitive epigenomic profiling. Drugs targeting currently being explored, though but specificity pathogenetic remains elusive. amenability cutaneous topical therapies elevate usefulness this common skin disorder.