A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice
作者： Ana Maria Valencia-Hernandez , Wei Yi Ng , Nazanin Ghazanfari , Sonia Ghilas , Maria N. de Menezes
DOI: 10.1016/J.CHOM.2020.04.010
关键词:
摘要: Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter can mediate efficient protection against liver-stage Plasmodium infection. This finding has prompted development of immunization strategies where T cells are activated spleen then trapped form TRM cells. Here, we identify PbRPL6120-127, a H2-Kb-restricted epitope from putative 60S ribosomal protein L6 (RPL6) berghei ANKA, as an optimal for endogenous cell generation malaria. A single dose vaccination targeting RPL6 provided effective prolonged sterilizing high sporozoite challenges. Expressed throughout parasite life cycle, across species, highly conserved, exhibits strong translation potential vaccine candidate. is further advocated by identification broadly immunogenic HLA-A∗02:01-restricted P. falciparum RPL6.
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