Expression of zinc transporter ZnT7 in mouse superior cervical ganglion
作者： Hui-Ling Gao , He Xu , Xin Wang , Annica Dahlstrom , Liping Huang
DOI: 10.1016/J.AUTNEU.2008.04.002
关键词:
摘要: The superior cervical ganglion (SCG) neurons contain a considerable amount of zinc ions, but little is known about the homeostasis in SCG. It that transporter 7 (ZnT7, Slc30a7), member Slc30 ZnT family, involved mobilizing ions from cytoplasm into Golgi apparatus. In present study, we examined expression and localization ZnT7 labile mouse SCG using immunohistochemistry, Western blot vivo selenium autometallography (AMG). Our immunohistochemical analysis revealed immunoreactivity was predominately perinuclear region neurons, suggesting an affiliation to results verified protein expressed SCGs. AMG reaction product shown have similar distribution as immunoreactivity. These observations support notion may participate transport, storage, incorporation zinc-binding proteins apparatus neurons.
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sci-hub.se 参考文章(56)
Péter Molnár, J. Victor Nadler, Lack of Effect of Mossy Fiber-Released Zinc on Granule Cell GABAA Receptors in the Pilocarpine Model of Epilepsy Journal of Neurophysiology. ,vol. 85, pp. 1932- 1940 ,(2001) , 10.1152/JN.2001.85.5.1932
David W. Christianson, Structural biology of zinc. Advances in Protein Chemistry. ,vol. 42, pp. 281- 355 ,(1991) , 10.1016/S0065-3233(08)60538-0
Atsushi Takeda, Zinc homeostasis and functions of zinc in the brain Biometals. ,vol. 14, pp. 343- 351 ,(2001) , 10.1023/A:1012982123386
Taiho Kambe, Hiroshi Narita, Yuko Yamaguchi-Iwai, Junko Hirose, Tatsuaki Amano, Naomi Sugiura, Ryuzo Sasaki, Koshi Mori, Toshihiko Iwanaga, Masaya Nagao, Cloning and Characterization of a Novel Mammalian Zinc Transporter, Zinc Transporter 5, Abundantly Expressed in Pancreatic β Cells Journal of Biological Chemistry. ,vol. 277, pp. 19049- 19055 ,(2002) , 10.1074/JBC.M200910200
L. Alex Gaither, David J. Eide, Eukaryotic zinc transporters and their regulation. Biometals. ,vol. 14, pp. 251- 270 ,(2001) , 10.1023/A:1012988914300
JY Koh, DW Choi, Zinc alters excitatory amino acid neurotoxicity on cortical neurons. The Journal of Neuroscience. ,vol. 8, pp. 2164- 2171 ,(1988) , 10.1523/JNEUROSCI.08-06-02164.1988
P D Zalewski, I J Forbes, W H Betts, Correlation of apoptosis with change in intracellular labile Zn(II) using zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)acetic acid], a new specific fluorescent probe for Zn(II) Biochemical Journal. ,vol. 296, pp. 403- 408 ,(1993) , 10.1042/BJ2960403
Tony Valente, Carme Auladell, Jeús Pérez-Clausell, Postnatal development of zinc-rich terminal fields in the brain of the rat. Experimental Neurology. ,vol. 174, pp. 215- 229 ,(2002) , 10.1006/EXNR.2002.7876
Christopher J. Frederickson, Shawn C. Burdette, Cathy J. Frederickson, Stefano L. Sensi, John H. Weiss, Hong Z. Yin, Rengarajan V. Balaji, Ai Q. Truong-Tran, Eric Bedell, Donald S. Prough, Stephen J. Lippard, Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor. Journal of Neuroscience Methods. ,vol. 139, pp. 79- 89 ,(2004) , 10.1016/J.JNEUMETH.2004.04.033
Yan Yiu Yu, Catherine P. Kirschke, Liping Huang, Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract. Journal of Histochemistry and Cytochemistry. ,vol. 55, pp. 223- 234 ,(2007) , 10.1369/JHC.6A7032.2006