Genetics of sarcoidosis.

摘要: Sarcoidosis is a multifactorial and polygenic disorder. Recently, several novel predisposing genes have been identified by genome-wide association studies, fast progress in molecular technologies such as systematic large-scale resequencing will aid the discovery of further risk loci variants. In this article, current knowledge its genetics be presented, including known candidate variants loci, with focus on human leukocyte antigen region. Some these factors are shared other, clinically distinct diseases. This may lead to development new hypotheses pathomechanisms, which associate sarcoidosis other granulomatous disorders but also diseases significantly different phenotypes. near future system, biology approaches help unravel differing common features allow therapeutic strategies tools predict course response treatment individual patients.