Composite biodegradable biopolymer coatings of silk fibroin – Poly(3-hydroxybutyric-acid-co-3-hydroxyvaleric-acid) for biomedical applications

摘要: Abstract Composite silk fibroin–poly(3-hydroxybutyric-acid-co-3-hydroxyvaleric-acid) (SF–PHBV) biodegradable coatings were grown by Matrix Assisted Pulsed Laser Evaporation on titanium substrates. Their physico-chemical properties and particularly the degradation behavior in simulated body fluid at 37 °C studied as first step of applicability local controlled release for tissue regeneration applications. SF PHBV, natural biopolymers with excellent biocompatibility, but different biodegradability tensile strength properties, combined a composite to improve their biomedical uses. FTIR analyses showed stoichiometric transfer from targets presence spectra main absorption maxima characteristic both polymers. XRD investigations confirmed results showing differences crystallization respect PHBV content. Contact angle values obtained through wettability measurements indicated MAPLE deposited highly hydrophilic; surfaces turning hydrophobic increase component. Degradation assays proved that higher contents resulted enhanced resistance slower rate SBF. Distinct drug-release schemes could be adjusting SF:PHBV ratio controllably tuning rate, rapid-release formulas, where predominates, prolonged sustained ones, larger