Platinum(iv) azido complexes undergo copper-free click reactions with alkynes.
作者： Nicola J. Farrer , Gitanjali Sharma , Rachel Sayers , Evyenia Shaili , Peter J. Sadler
DOI: 10.1039/C7DT04183G
关键词:
摘要: We report our investigations into the first examples of copper-free 1,3-dipolar cycloaddition (click) reactions electrophiles with a PtIV azido complex. The Pt-IV complex trans, trans-[PtIV(py)2(N3)2(OH)2] (1) was reactive towards dimethyl acetylenedicarboxylate (DMAD) (2), diethyl DEACD (3), N-[(1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethyloxycarbonyl]-1,8-diamino-3,6-dioxaoctane (BCN) (11) and dibenzocyclooctyne-amine (DBCO) (12) resulting in formation corresponding mono (a) bis-substituted (b) complexes. Complexes 2 undergo further between Pt centre carbonyl group to form 2a′ 2b′. This is not seen for products PtII trans-[Pt(py)2(N3)2] acetylene 2. Novel complexes 2a′, 2b′, 11a 11b have been characterised by multinuclear NMR, IR UV-vis spectroscopy ESI-MS. These represent new synthetic routes novel Pt(IV)
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