Interactions of a few azole derivatives with a transport protein: role of heteroatoms.

摘要: The interaction of a few azole derivatives, 2-(4'-N,N-dimethylaminophenyl)benzimidazole, 2-(4'-N,N-dimethylaminophenyl)benzoxazole, 2-(4'-N,N-dimethylaminophenyl)oxazolo[4,5-b]pyridine with bovine serum albumin (BSA) were examined by absorption and fluorescence spectroscopy. results compared the previously studied imidazopyridine derivative 2-(4'-N,N-dimethylaminophenyl)imidazo[4,5-b]pyridine. Displacement studies carried out site selective probes to locate binding these ligands. spectral shifts constant vary depending on nature ligand. intensity both oxazole derivatives 2-(4'-N,N-dimethylaminophenyl)benzoxazole 2-(4'-N,N-dimethylaminophenyl) oxazolo[4,5-b]pyridine increases substantially in presence BSA, whereas 2-(4'-N,N-dimethylaminophenyl)benzimidazole decreases. However, hypsochromic shift is observed BSA. obtained from docking are also good agreement experimental results. location orientation depend upon revealed that apart hydrophobic interaction, hydrogen bonding plays vital role molecular binding. Oxazoles have higher affinity than imidazoles substitution extra nitrogen further affinity.