Apple‐ and Hop‐Polyphenols Inhibit Porphyromonas gingivalis‐Mediated Precursor of Matrix Metalloproteinase‐9 Activation and Invasion of Oral Squamous Cell Carcinoma Cells
作者： Hiroaki Inaba , Motoyuki Tagashira , Tomomasa Kanda , Yukitaka Murakami , Atsuo Amano
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摘要: Background: Recent epidemiologic studies have revealed a significant association between periodontitis and oral squamous cell carcinoma (OSCC). Furthermore, is markedly associated with orodigestive cancer mortality, whereas Porphyromonas gingivalis (Pg) infection has been identified as specific potentially independent microbial factor related to increased risk of death. The authors previously reported that Pg induced the precursor form matrix metalloproteinase-9 (proMMP-9) production via proteinase-activated receptor (PAR)-related pathways, after which proMMP-9 was activated by gingipains enhance cellular invasion SAS cells. In present study, effects selected polyphenols inhibitors caused in cells are examined.Methods: OSCC were infected strains including gingipain mutants. To evaluate inhibitors: 1) apple polyphenol (AP); 2) hop bract (HBP); 3) high-molecular-weight fra...
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