Polymorphisms of a human variable heavy chain gene show linkage with constant heavy chain genes

摘要: In this study, restriction fragment length polymorphisms (RFLPs) were identified with an immunoglobulin variable heavy chain region (Ig VH) probe and the inheritance of was analyzed in families. Linkage within VHII gene cluster between Ig CH genes investigated by lod (logarithm odds) score analysis. addition, position determined relation to another polymorphic locus--D14S1, which is tightly linked centromeric genes. Genetic associations VH clusters analyzed. These RFLPs represent genetically characterized it hoped that they will facilitate study disease correlations as well further understanding genetics humans.