5-oxoproline-induced anion gap metabolic acidosis after an acute acetaminophen overdose.
作者： Nathan P Charlton , Christopher P Holstege , David T Lawrence , Laura K Bechtel
DOI: 10.7556/JAOA.2010.110.9.545
关键词:
摘要: Metabolic acidosis after acute acetaminophen overdose is typically attributed to either transient lactic without evidence of hepatic injury or failure. High levels the organic acid 5-oxoprolinuria are usually reported in patients with predisposing conditions, such as sepsis, who treated a subacute chronic fashion acetaminophen. The authors report case 40-year-old woman developed anion gap metabolic and somnolence an overdose. Substantial damage did not occur, which ruled out acetaminophen-induced insufficiency cause patient's altered mental status. Urinalysis revealed elevated 5-oxoproline, suggesting that was associated marked due solely 5-oxoproline complications. fully resolved N-acetylcysteine treatment supportive care including hydration.
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