Age effect on thyroid hormone brain response in male mice

摘要: Thyroid hormones (TH) are important for brain development and central nervous system (CNS) function. Disturbances of thyroid function occur with higher prevalence in the ageing population may negatively impact We investigated age on behavior young adult old male mice (5 vs. 20 months) chronic hypo- or hyper-thyroidism as well sham-treated controls. Expression TH transporters responsive genes was studied CNS pituitary by situ hybridization qRT-PCR, whereas serum concentrations were determined immunoassay. Serum levels lower compared hyperthyroid mice, suggesting a milder phenotype aged group. Likewise, elevated plus maze activity reduced animals. Under hypothyroid conditions, thyroxine did not differ mice. Both groups showed comparable decline anxiety levels. However, an attenuated increase hypothalamic thyrotropin releasing hormone stimulating transcript expression found Brain monocarboxylate transporter 8 organic anion transporting polypeptide 1c1 affected status. In summary, attenuates neurological phenotypes but which fits effects contrast no changes mouse brains hyper- hypo-thyroid state.